(2S)-3-(4-acetamido-phenoxy)-2-hydroxy-2-methyl-N-(4-nitro-3-trifluoromethyl-phenyl)-propionamide S4 (Andarine) is an investigational selective androgen receptor modulator (SARM) developed on GTX.INC on the side of treatment of conditions such as muscle wasting, osteoporosis and benign prostatic hypertrophy, us the non-steroidal androgen competitor bicalutamide as a steer compound. Andarine is an orally energetic feeling an attraction agonist after androgen receptors. In an uncultured working model of sympathetic prostatic hypertrophy, andarine was shown to abridge prostate burden with nearly the same efficacy to finasteride, but without producing any reduction in muscle mass or anti-androgenic side effects.This suggests that it is able to competitively block binding of dihydrostestosterone to its receptor targets in the prostate gland, but its prejudiced agonist effects at androgen receptors proscribe the side effects associated with the anti-androgenic drugs traditionally worn to save treatment of BPH. S-4 (3 mg/kg/day) was also clever to reinvigorate skeletal muscle (i.e., soleus muscle) and strength in castrated rats, urgent and appropriate for the treatment of muscle wasting and spear HRT. A 120-day review comparing SARM S-4 and dihydrotestosterone (DHT) treatment in ovariectomized rats demonstrated that S-4 was masterly to maintain bone assemble and bone strength to the levels of unbroken controls and exhibited greater efficacy than DHT. Testosterone shows a exact nearly the same raise in muscle and prostate flowering in a dose dependent bearing where S-4 shows a great growth in muscle broadening with prostate extension staying basically uniform. S-4 also demonstrated the wit to improve skeletal muscle toughness, dilate wasted company accumulation (LBM), break thickness pot-bellied, and enjoin bone loss. From http://www.tcsindustry.com - TCS INDUSTRY LTD